Scientific activity

Her scientific activity is dealt with learning of connective tissues biochemistry in the fields of orthopaedics and traumatology and oncology.

Prof. Knyaseva M. devoted her student time to learning of tumor radiosensibility. Severel written and published articles in famous scientific journals such as " Questions of Oncology ", 1981 and " Radiobiology ", 1982 were the result of this work.

In 1988 she defended her candidate dissertation " The pecularities of carbo-hydrate metabolism in the spine tissues under hypokinesia and emotion-painful stress".

In 1996 she defended her doctor`s dissertation " Metabolic characteristics of changes in tissues of bone-joint and hard-vessels systems under stress".

This investigation was continued with learning of metabolic processes on bone and cartilage tissues under stress.

It is known that disorder in bone and cartilage tissues metabolism cause their distructive changes.

The fact that pathology can be the result of desintegration of metabo-lic processes between tissues of different organs - was taken into considera-tion in this work.

The model "Experimental osteochondrose" and several kinds of radio-logy markers were used in this work.

It was proved the existence of links of desintegration of metabolic processes between tissues of intervertebral disks, verbs, compact tissue of thigh, aorta, myocard and liver.

In this work the author for the first time tried to formulate biochemical criteria of change of intervertebral disk tissue from normal condition to pathology.

During the analysis of clinical material taken from patients with osteochondrosis and acute myocardical infarction common mechanism of pathogenesis of these diseases was discribed.

It should be admited that connective tissues biochemistry investigations were used in the oncogynicology area for prognosis of the ovarian cancer development and for monitory of chemistry therapy effect. These results were used for finding out the criteria of the aneurysm rupture.

At present time she has prepared the monography called " Stress-desintegration-pathology ", where her main scientific ideas were presented.

Prof. Knyaseva M. is the author of 73 scientific published works, including 4 inventions, 3 patents. Among them are: " The device for investigation of animal activity " (n 891067, USSR,1987 ).

" The way of separating of polymorphnonuclear lyucosites from human blood" (Patent of Ukraine N 20013A).

" The way of determination of myocardical infarction development processes phase"." The way of prognosis of ovarian cancer treatment efficiency".

The main trends of her scientific activity nowadays are:

- investigation of metabolism in normal and pathologic connective tissues at different deseases;

- investigation of interaction of bone-jointed sistem with other physiological systems of organism.

Since 1981 Prof. Knyaseva M. has been an active member of congresses of specialists of clinical laboratory diagnostics, biochemistry, oncology, orthopaedics and traumatology and so on.

Her scientific works were published in Journals "Orthopaedics, traumatology and prosthesis" (1985, 1994, 1995,1999, 2000, 2001);

"Ukrainian biochemical journal (1995, N6);

"Laboratory diagnostics", Kiev, (1998, 1999, 2001).

Among latest articles written by her are " The perspectives of investigation of newtrophyl activation in prognosis of osteochondrosis with other deseases combinations" (Orth, traum and protes., 2001, N2);

" The perspectives of investigation of newtrophyl activation in prognosis of osteochondrosis aggravation in sharp myocardical infarction" (Laboratory diagnostics, N2, 2001);

"The Hormonal breaches and pathogenesis of ovarian cancer" (Oncology, Kiev, 2001).

Recently she has been the member of Edition Council and author of severel articles in the Journal "Laboratory diagnostics" (The Head Editor is famous Ukrainian professor Gromashevskaya L.L.).

"About biochemistry teaching at medical departments in Ukraine according to the problem-based-learning (PBL) method" (Medical Chemistry, Scientific Journal, Ternopil, 2004 V.6, N3.-P.129-133).

She proposes any form of cooperation in modern scientific trends to approach the topic from interdisciplinary perspective.

 

FEBS ANNIVERSARY CELEBRATION

By Marina Knyazeva, Ph.D. and Professor of Biochemistry Department in Kharkov National University, Member of the Ukrainian Biochemical Society, One of the winners of a free registration to the 2004 FEBS Congress in Warsaw

CHALLENGES FOR EUROPEAN SCIENCE (III/IV)

Highly appreciating the significance of FEBS informational letters in uniting biochemists and molecular biologists of the world, I would like to call attention to the problem we are facing in our country ( Ukraine ).

I have devoted 23 years of my life to the problems of applying biochemistry in Orthopaedics and Traumatology, oncological gynaecology, cardiology and cardiovascular surgery (see e.g. http://www.mknyazeva. narod.ru ).

Unfortunately the teaching and training programmes in biochemistry at Medical departments of our Universities do not provide a course of clinical biochemistry as a special subject (see the materials of the VIII Ukrainian Biochemistry Congress, Chernovtsy, 2002//

The Ukrainian Biochemical Journal. Vol.74, N4a (Supplement 1), 2002.-P.196-208 ) which results in a considerable gap between theoretical knowledge and clinical practice.

Since biochemical methods of investigation provide a considerable part of diagnostic information, the practitioners’ inability to interpret the results of biochemical analyses may cause grave diagnostic mistakes.

That is why it is utterly necessary to work out a programme including a special course of “clinical biochemistry” to develop a sort of “clinical thinking” - a system of methods of applying biochemical data iin therapy.

Exchanging experience with our European colleagues at the FEBS- 2004 Congress might of great help to us and I look forward to join the celebration.